CD3-INDUCED T-CELL PROLIFERATION AND INTERLEUKIN-2 SECRETION IS MODULATED BY THE CD45 ANTIGEN

被引：20

作者：

ORAVECZ, T ^{[1
]}

MONOSTORI, E ^{[1
]}

KURUCZ, E ^{[1
]}

TAKACS, L ^{[1
]}

ANDO, I ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI, IMMUNOL LAB, H-6701 SZEGED, HUNGARY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1991年 / 34卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1991.tb01576.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study we have investigated the effect of CD45, CD45RA and CD45RO monoclonal antibodies (MoAbs) on the CD3 receptor-mediated proliferation of human T lymphocytes. It is shown that CD3-induced proliferation of purified resting T cells and quiescent T lymphoblasts (QTL) is promoted via all of the investigated CD45-associated epitopes. It is also shown that the CD45 molecules are required to be cross-linked for costimulation. The MoAbs enhance the interleukin-2 (IL-2) production of CD3-stimulated QTL. The elevation of the IL-2 production correlates with the increase in CD3-induced cell proliferation suggesting that the CD45-driven regulation of T lymphocyte activation is linked to the IL-2 pathway.

引用

页码：531 / 537

页数：7

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