CD3-INDUCED T-CELL PROLIFERATION AND INTERLEUKIN-2 SECRETION IS MODULATED BY THE CD45 ANTIGEN

被引：20

作者：

ORAVECZ, T ^{[1
]}

MONOSTORI, E ^{[1
]}

KURUCZ, E ^{[1
]}

TAKACS, L ^{[1
]}

ANDO, I ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI, IMMUNOL LAB, H-6701 SZEGED, HUNGARY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1991年 / 34卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1991.tb01576.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study we have investigated the effect of CD45, CD45RA and CD45RO monoclonal antibodies (MoAbs) on the CD3 receptor-mediated proliferation of human T lymphocytes. It is shown that CD3-induced proliferation of purified resting T cells and quiescent T lymphoblasts (QTL) is promoted via all of the investigated CD45-associated epitopes. It is also shown that the CD45 molecules are required to be cross-linked for costimulation. The MoAbs enhance the interleukin-2 (IL-2) production of CD3-stimulated QTL. The elevation of the IL-2 production correlates with the increase in CD3-induced cell proliferation suggesting that the CD45-driven regulation of T lymphocyte activation is linked to the IL-2 pathway.

引用

页码：531 / 537

页数：7

共 35 条

[1]

ANDO I, 1984, TISSUE CULTURE RES, P241

[2] INTERLEUKIN-2 (IL-2)-INDUCED TYROSINE PHOSPHORYLATION OF IL-2 RECEPTOR-P75 [J].

ASAO, H ;

TAKESHITA, T ;

NAKAMURA, M ;

NAGATA, K ;

SUGAMURA, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (03) :637-644

[3]

BERNARD A, 1986, LEUCOCYTE TYPING 2, V3, P53

[4]

BERNSTEIN ID, 1986, LEUCOCYTE TYPING 2, V1, P1

[5]

COBBOLD S, 1987, LEUKOCYTE TYPING, V3, P788

[6]

DAVIS LS, 1989, J IMMUNOL, V142, P1084

[7]

HUET S, 1986, J IMMUNOL, V137, P1420

[8]

LEDBETTER JA, 1985, J IMMUNOL, V135, P1819

[9] CD45 REGULATES SIGNAL TRANSDUCTION AND LYMPHOCYTE-ACTIVATION BY SPECIFIC ASSOCIATION WITH RECEPTOR MOLECULES ON T-CELLS OR B-CELLS [J].

LEDBETTER, JA ;

TONKS, NK ;

FISCHER, EH ;

CLARK, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) :8628-8632

[10] A 2ND SIGNAL FOR T-CELL MITOGENESIS PROVIDED BY MONOCLONAL-ANTIBODIES CD45 (T200) [J].

MARTORELL, J ;

VILELLA, R ;

BORCHE, L ;

ROJO, I ;

VIVES, J .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (10) :1447-1451

← 1 2 3 4 →