P53 AND CATHEPSIN-D ARE INDEPENDENT OF ESTABLISHED PROGNOSTIC FACTORS IN BREAST-CANCER

被引：0

作者：

SILVESTRINI, R ^{[1
]}

VENERONI, S ^{[1
]}

BENINI, E ^{[1
]}

DIFRONZO, G ^{[1
]}

DAIDONE, MG ^{[1
]}

机构：

[1] CNR,CTR STUDIO PATOL CELLULARE,I-20133 MILAN,ITALY

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1992年 / 1卷 / 05期

关键词：

P53; CATHEPSIN-D; PROLIFERATIVE ACTIVITY; PLOIDY; STEROID RECEPTORS; BIOLOGIC CHARACTERIZATION; BREAST CANCER;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p53 and cathepsin D expression was investigated in 300 primary breast cancers by the avidin-biotin immunoperoxidase method using two murine monoclonal antibodies: PAb1801 and anti-procathepsin D, respectively. The frequency of p53- and cathepsin D-positive cells varied widely among different tumors and most tumors (82% and 86%) at least occasionally showed positive cells. The two biological markers were unrelated to one another, to cell proliferative rate and ploidy and were differently related to other biological and pathological features. In particular, p53 was directly related to tumor size and nodal involvement and inversely related to the presence of steroid receptors. Conversely, cathepsin D was directly related only to nodal involvement.

引用

页码：507 / 512

页数：6

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