PALM OIL VITAMIN-E PROTECTS AGAINST ISCHEMIA REPERFUSION INJURY IN THE ISOLATED PERFUSED LANGENDORFF HEART

被引：42

作者：

SERBINOVA, E

KHWAJA, S

CATUDIOC, J

ERICSON, J

TORRES, Z

GAPOR, A

KAGAN, V

PACKER, L

机构：

[1] PALM OIL RES INST MALAYSIA,PETI SURAT 10620,KUALA LUMPUR 50720,MALAYSIA

[2] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

来源：

NUTRITION RESEARCH | 1992年 / 12卷

基金：

美国国家卫生研究院;

关键词：

PALM OIL VITAMIN-E; LANGENDORFF HEART; ISCHEMIA-REPERFUSION; LDH; ATP; CREATINE PHOSPHATE; ALPHA-TOCOPHEROL; ALPHA-TOCOTRIENOL;

D O I：

10.1016/S0271-5317(05)80464-6

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We studied the effect of palm oil vitamin E on Langendorff perfused rat hearts subjected to 40 minutes of global ischemia. Our results demonstrated that palm oil vitamin E was more efficient in the protection of isolated Langendorff heart against ischemia/reperfusion injury than tocopherol as measured by its mechanical recovery. Palm oil vitamin E completely suppressed LDH enzyme leakage from ischemic hearts, prevented the decrease in ATP and creatine phosphate levels and inhibited the formation of endogenous lipid peroxidation products. Our data indicate that a palm oil vitamin E mixture containing both alpha-tocopherol and alpha-torotrienol may be more efficient than alpha-tocopherol alone in the protection of the heart against oxidative stress induced by ischemia-reperfusion.

引用

页码：S203 / S215

页数：13

共 23 条

[1] REPERFUSION INJURY [J].