CHANGES IN PLATELET MEMBRANE FLUIDITY OF MIGRAINE PATIENTS

被引：11

作者：

COTRIM, MD

RIBEIRO, CAF

DEMACEDO, TDA

机构：

[1] UNIV COIMBRA,FAC MED,INST PHARMACOL & EXPTL THERAPEUT,P-3400 COIMBRA,PORTUGAL

[2] UNIV COIMBRA,FAC MED,DEPT NEUROL,P-3400 COIMBRA,PORTUGAL

来源：

CEPHALALGIA | 1993年 / 13卷 / 02期

关键词：

MEMBRANE FLUIDITY; MIGRAINE; PLATELETS; TMA-DPH;

D O I：

10.1046/j.1468-2982.1993.1302099.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Platelet membrane fluidity was measured in migraine patients, with and without aura, using the fluorescent probe TMA-DPH (1-[4-(trimethylammonium) phenyl]-6-hexa-1,3,5-triene). Polarization values for TMA-DPH were significantly higher in the platelet membranes of migraine patients (with or without aura) than in those of healthy subjects. These findings signify decreased membrane fluidity and may explain some modifications in receptors, carriers or enzymes described in platelets of migraine patients.

引用

页码：99 / 101

页数：3

共 16 条

[1]

CARAMONA MM, 1990, J NEURAL TRANSM, V32, P161

[2]

COTRIM MD, 1989, J NEUROCHEMISTRY S, V52, pSC79

[3]

DAVIDSON J, 1984, P IEEE CS INT C DATA, P69

[4] MEMBRANE FLUIDITY OF NONACTIVATED AND ACTIVATED HUMAN BLOOD-PLATELETS [J].