Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma

被引:1
作者
Larsson, Patricia [1 ,2 ]
Arvidsson, Dag [3 ]
Bjornstedt, Mikael [4 ]
Isaksson, Bengt [5 ]
Jersenius, Ulf [5 ]
Motarjemi, Hooman [5 ]
Jacobsson, Hans [1 ,2 ]
机构
[1] Karolinska Univ Hosp Solna, Dept Radiol, Solna, Sweden
[2] Karolinska Univ Hosp Solna, Dept Nucl Med, Solna, Sweden
[3] Karolinska Univ Hosp Solna, Dept Surg, Stockholm, Sweden
[4] Karolinska Univ Hosp Huddinge, Dept Pathol, Huddinge, Sweden
[5] Karolinska Univ Hosp Huddinge, Dept Surg Gastroenterol, Huddinge, Sweden
关键词
(C-11)-acetate; 18F-FDG; Hepatocellular carcinoma; tomography; positron-emission; sensitivity;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: The sensitivity of FDG at PET examination of Hepatocellular Carcinoma (HCC) is restricted. In a few studies, all done in Oriental patients, PET-examination with 11C-acetate has shown a higher accuracy than with FDG. In the current study, the uptake of 11C-acetate has been compared with the uptake of FDG in the primary HCC in a cohort of Occidental patients. Material and Methods: 44 patients underwent PET-examination with both tracers with a mean of 9 days between the examinations. 26 patients had a microscopical diagnosis and 18 were diagnosed with multimodal radiological methods. At least one relevant radiological examination was available for comparison. Results: At visual evaluation, 13 of the HCC's were positive at PET-examination using FDG and 34 were positive using C-11-acetate (p<0.001). Median tumor SUVmean of C-11-acetate was 4.7 and of FDG was 1.9 (p<0.001). There was also a higher uptake of C-11-acetate by the surrounding liver tissue than of FDG. Median liver SUVmean of C-11-acetate was 3.2 and of FDG it was 1.7 (p<0.001). This corresponded to a median tumour/liver tissue ratio for C-11-acetate of 1.4 and for FDG of 1.0 (p<0.05). Previous reports of a negative correlation between the uptake of the tracers were weakly supported. In 4 large tumors some portions being hot using one of the tracers were cold using the other tracer and vice versa. Conclusion: Adding registration with 11C-acetate to registration with FDG at PET-examination has an incremental value in the diagnosis of HCC. A higher tumor uptake of 11C-acetate cannot be taken full advantage of because of a higher uptake also by the surrounding liver tissue.
引用
收藏
页码:6 / 12
页数:7
相关论文
共 22 条
[1]   Clinical management of hepatocellular carcinoma.: Conclusions of the Barcelona-2000 EASL Conference [J].
Bruix, J ;
Sherman, M ;
Llovet, JM ;
Beaugrand, M ;
Lencioni, R ;
Burroughs, AK ;
Christensen, E ;
Pagliaro, L ;
Colombo, M ;
Rodés, J .
JOURNAL OF HEPATOLOGY, 2001, 35 (03) :421-430
[2]   Can Positron Emission Tomography with the Dual Tracers [11C] Acetate and [18F] Fludeoxyglucose Predict Microvascular Invasion in Hepatocellular Carcinoma? [J].
Cheung, Tan To ;
Chan, See Ching ;
Ho, Chi Lai ;
Chok, Kenneth Siu Ho ;
Chan, Albert Chi Yan ;
Sharr, William Wei ;
Ng, Kelvin Kwok Chai ;
Poon, Ronnie Tung Ping ;
Lo, Chung Mau ;
Fan, Sheung Tat .
LIVER TRANSPLANTATION, 2011, 17 (10) :1218-1225
[3]   Evaluation of benign vs malignant hepatic lesions with positron emission tomography [J].
Delbeke, D ;
Martin, WH ;
Sandler, MP ;
Chapman, WC ;
Wright, JK ;
Pinson, CW .
ARCHIVES OF SURGERY, 1998, 133 (05) :510-515
[4]  
Delbeke D, 2003, J NUCL MED, V44, P222
[5]   Imaging of Proliferation in Hepatocellular Carcinoma with the In Vivo Marker 18F-Fluorothymidine [J].
Eckel, Florian ;
Herrmann, Ken ;
Schmidt, Stefan ;
Hillerer, Claudia ;
Wieder, Hinrich A. ;
Krause, Bernd-Joachim ;
Schuster, Tibor ;
Langer, Rupert ;
Wester, Hans-Juergen ;
Schmid, Roland M. ;
Schwaiger, Markus ;
Buck, Andreas K. .
JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (09) :1441-1447
[6]   Epidemiology of hepatocellular carcinoma in USA [J].
El-Serag, Hashem B. .
HEPATOLOGY RESEARCH, 2007, 37 :S88-S94
[7]   Hepatitis B and C virus-related carcinogenesis [J].
Fung, J. ;
Lai, C. -L. ;
Yuen, M. -F. .
CLINICAL MICROBIOLOGY AND INFECTION, 2009, 15 (11) :964-970
[8]   Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma [J].
Ho, Chi-Lai ;
Chen, Sirong ;
Yeung, David W. C. ;
Cheng, Thomas K. C. .
JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (06) :902-909
[9]  
Ho CL, 2003, J NUCL MED, V44, P213
[10]   Evaluation of patients with hepatocellular carcinomas using [11C]acetate and [18F]FDG PET/CT: A preliminary study [J].
Hwang, Kyung Hoon ;
Choi, Duck-Joo ;
Lee, Sang-Yoon ;
Lee, Min Kyung ;
Choe, Wonsick .
APPLIED RADIATION AND ISOTOPES, 2009, 67 (7-8) :1195-1198