Engineering generic vaccine vectors

被引：0
作者：
Sudhakar, Poda [1 ]
Kiranmayi, M. Usha [2 ]
Sankarpandian, Selvaraj [1 ]
Rao, Manyam Srinivasa [1 ]
Vijayalakshmi, M. [3 ]
Rao, K. R. S. Sambasiva [1 ]
机构：
[1] Acharya Nagarjuna Univ, Ctr Biotechnol, Guntur 522510, Andhra Pradesh, India
[2] Sri Krishnadevaraya Univ, Dept Microbiol, Anantapur 515003, Andhra Pradesh, India
[3] Acharya Nagarjuna Univ, Dept Microbiol, Guntur 522510, Andhra Pradesh, India
来源：
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING AND TECHNOLOGY | 2011年 / 6卷 / 01期
关键词：
engineering vaccines; promoter; vector;
D O I：
10.1504/IJBET.2011.040455
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
DNA vaccine engineering has become the favoured strategy for inducing immunity. The molecular precision offered to direct and amplify the immunity by the gene-based vaccines has always been attractive. The design of the vector is the most important aspect to be considered, as several factors such as promoter, enhancer, codon choice and genetic adjuvants are the key elements that control the expression of the cloned antigen gene. The review helps to consider the manufacturing ease and factors that are to be taken into account while constructing the vector.
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页码：93 / 108
页数：16
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