CDC25 PHOSPHATASES AS POTENTIAL HUMAN ONCOGENES

被引：513
作者：
GALAKTIONOV, K
LEE, AK
ECKSTEIN, J
DRAETTA, G
MECKLER, J
LODA, M
BEACH, D
机构：
[1] COLD SPRING HARBOR LAB, HOWARD HUGHES MED INST, COLD SPRING HARBOR, NY 11724 USA
[2] HARVARD UNIV, SCH MED, LAHEY CLIN MED CTR, BURLINGTON, MA 01805 USA
[3] MITOTIX, CAMBRIDGE, MA 02139 USA
[4] HARVARD UNIV, DEACONESS HOSP, SCH MED, DEPT PATHOL, BOSTON, MA 02215 USA
来源：
SCIENCE | 1995年 / 269卷 / 5230期
关键词：
D O I：
10.1126/science.7667636
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RAS(G12V) or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.
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收藏
页码：1575 / 1577
页数：3
相关论文
共 46 条
[1]   ABNORMAL P53 IMMUNOREACTIVITY AND PROGNOSIS IN NODE-NEGATIVE BREAST CARCINOMAS WITH LONG-TERM FOLLOW-UP [J].
BOSARI, S ;
LEE, AKC ;
VIALE, G ;
HEATLEY, GJ ;
COGGI, G .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1992, 421 (04) :291-295
[2]   CYTOPLASMIC ACCUMULATION OF P53 PROTEIN - AN INDEPENDENT PROGNOSTIC INDICATOR IN COLORECTAL ADENOCARCINOMAS [J].
BOSARI, S ;
VIALE, G ;
BOSSI, P ;
MAGGIONI, M ;
COGGI, G ;
MURRAY, JJ ;
LEE, AKC .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (09) :681-687
[3]   MICROVESSEL QUANTITATION AND PROGNOSIS IN INVASIVE BREAST-CARCINOMA [J].
BOSARI, S ;
LEE, AKC ;
DELELLIS, RA ;
WILEY, BD ;
HEATLEY, GJ ;
SILVERMAN, ML .
HUMAN PATHOLOGY, 1992, 23 (07) :755-761
[4]   ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS [J].
COWLEY, S ;
PATERSON, H ;
KEMP, P ;
MARSHALL, CJ .
CELL, 1994, 77 (06) :841-852
[5]   WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION [J].
ELDEIRY, WS ;
TOKINO, T ;
VELCULESCU, VE ;
LEVY, DB ;
PARSONS, R ;
TRENT, JM ;
LIN, D ;
MERCER, WE ;
KINZLER, KW ;
VOGELSTEIN, B .
CELL, 1993, 75 (04) :817-825
[6]   CYCLIN - A PROTEIN SPECIFIED BY MATERNAL MESSENGER-RNA IN SEA-URCHIN EGGS THAT IS DESTROYED AT EACH CLEAVAGE DIVISION [J].
EVANS, T ;
ROSENTHAL, ET ;
YOUNGBLOM, J ;
DISTEL, D ;
HUNT, T .
CELL, 1983, 33 (02) :389-396
[7]   SPECIFIC ACTIVATION OF CDC25 TYROSINE PHOSPHATASES BY B-TYPE CYCLINS - EVIDENCE FOR MULTIPLE ROLES OF MITOTIC CYCLINS [J].
GALAKTIONOV, K ;
BEACH, D .
CELL, 1991, 67 (06) :1181-1194
[8]   RAF1 INTERACTION WITH CDC25 PHOSPHATASE TIES MITOGENIC SIGNAL-TRANSDUCTION TO CELL-CYCLE ACTIVATION [J].
GALAKTIONOV, K ;
JESSUS, C ;
BEACH, D .
GENES & DEVELOPMENT, 1995, 9 (09) :1046-1058
[9]  
GALAKTIONOV K, UNPUB
[10]   TYROSINE PHOSPHORYLATION OF THE FISSION YEAST CDC2+ PROTEIN-KINASE REGULATES ENTRY INTO MITOSIS [J].
GOULD, KL ;
NURSE, P .
NATURE, 1989, 342 (6245) :39-45
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