In the 2lst century, scientists will introduce a manufacturing strategy based on machines and materials that virtually make themselves. Called self-assembly, it is easiest to define by what it is not. A self-assembling process is one in which humans are not actively involved, in which atoms, molecules, aggregates of molecules and components arrange themselves into ordered, functioning entities without human intervention. In contrast, most current methods of manufacturing involve a considerable degree of human direction. We, or machines that we pilot, control many important elements of fabrication and assembly. Self-assembly omits the human hand from the building. People may design the process, and they may launch it, but once under way it proceeds according to its own internal plan, either toward an energetically stable form or toward some system whose form and function are encoded in its parts. In the next few decades, materials scientists will begin deliberately to design machines and manufacturing systems explicitly incorporating the principles of self-assembly. The approach could have many advantages. It would allow the fabrication of materials with novel properties. It would eliminate the error and expense introduced by human labor. And the minute machines of the future envisioned by enthusiasts of so-called nanotechnology would almost certainly need to be constructed by self-assembly methods.