ETHANOL-INDUCED SIGNAL-TRANSDUCING MECHANISM ASSOCIATED WITH A TRANSIENT ANTIVIRAL STATE IN HUMAN AMNIOTIC CELLS

被引：3
作者：
MARKOVITS, A
PREMECZ, G
LORINCZ, I
BAGI, G
NAGY, J
FARKAS, T
FOLDES, I
机构：
[1] NATL INST HAEMATOL & BLOOD TRANSFUS,H-1502 BUDAPEST,HUNGARY
[2] FREDERIC JOLIOT CURIE NATL RES INST RADIOBIOL & R,BUDAPEST,HUNGARY
[3] NATL INST ALCOHOL,BUDAPEST,HUNGARY
[4] HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOCHEM,H-6701 SZEGED,HUNGARY
来源：
JOURNAL OF STUDIES ON ALCOHOL | 1994年 / 55卷 / 04期
关键词：
D O I：
10.15288/jsa.1994.55.495
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Short-term effects of ethanol on human amnion cells were investigated by studying the cellular signaling processes and the replication of vesicular stomatitis virus. Treatment of human amniotic cells with ethanol transiently triggers the breakdown of inositol phospholipids, stimulates intracellular [Ca2+](i) mobilization and activates the translocation of protein kinase C. Activation of this signal transduction mechanism is associated with the development of an antiviral state, as proven by studying H-3-uridine incorporation into the RNA of vesicular stomatitis virus. Induction of the antiviral state in human amniotic cells correlates with the solubility of the alcohols in the lipid membrane of the cells.
引用
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页码：495 / 502
页数：8
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