QUINAZOLINES AND 1,4-BENZODIAZEPINES .64. COMPARISON OF STEREOCHEMISTRY OF DIAZEPAM WITH THAT OF CLOSE ANALOGS WITH MARGINAL BIOLOGICAL-ACTIVITY

被引:51
作者
STERNBACH, LH [1 ]
SANCILIO, FD [1 ]
BLOUNT, JF [1 ]
机构
[1] HOFFMANN LAROCHE INC, CHEM RES DEPT, NUTLEY, NJ 07110 USA
关键词
D O I
10.1021/jm00249a032
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:374 / 377
页数:4
相关论文
共 10 条
[1]   STEREOCHEMICAL BASIS OF ANTICONVULSANT DRUG ACTION .2. MOLECULAR STRUCTURE OF DIAZEPAM [J].
CAMERMAN, A ;
CAMERMAN, N .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (01) :268-&
[2]   DIPHENYLHYDANTOIN AND DIAZEPAM - MOLECULAR STRUCTURE SIMILARITIES AND STERIC BASIS OF ANTICONVULSANT ACTIVITY [J].
CAMERMAN, A ;
CAMERMAN, N .
SCIENCE, 1970, 168 (3938) :1457-+
[3]   STEREOCHEMICAL BASIS OF ANTICONVULSANT DRUG ACTION .1. CRYSTAL AND MOLECULAR STRUCTURE OF DIPHENYLHYDANTOIN, A NONCENTROSYMMETRIC STRUCTURE SOLVED BY CENTRIC SYMBOLIC ADDITION [J].
CAMERMAN, A ;
CAMERMAN, N .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1971, B 27 (NOV15) :2205-&
[4]  
CAMERMAN N, 1971, MOL PHARMACOL, V7, P406
[5]   STEREOCHEMICAL BASIS OF ANTICONVULSANT DRUG ACTION .4. CRYSTAL AND MOLECULAR STRUCTURE OF TRIHEXYPHENIDYL [J].
CAMERMAN, N ;
CAMERMAN, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (24) :8553-&
[6]   ON APPLICATION OF PHASE RELATIONSHIPS TO COMPLEX STRUCTURES .2. GETTING A GOOD START [J].
GERMAIN, G ;
MAIN, P ;
WOOLFSON, MM .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1970, B 26 :274-&
[7]   QUINAZOLINES AND 1,4-BENZODIAZEPINES .25. STRUCTURE-ACTIVITY RELATIONSHIPS OF AMINOALKLY-SUBSTITUTED 1,4-BENZODIAZEPIN-2-ONES [J].
STERNBAC.LH ;
ARCHER, GA ;
EARLEY, JV ;
FRYER, RI ;
REEDER, E ;
WASYLIW, N ;
RANDALL, LO ;
BANZIGER, R .
JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (06) :815-&
[8]   QUINAZOLINES AND 1,4-BENZODIAZEPINES .6. HALO-, METHYL-, AND METHYOXY-SUBSTITUTED 1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES [J].
STERNBACH, LH ;
FRYER, RI ;
SAUCY, G ;
SACH, G ;
STEMPEL, A ;
METLESICS, W ;
REEDER, E .
JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (11) :3788-&
[9]  
STERNBACH LH, 1968, DRUGS AFFECTING CENT, V2, pCH6
[10]  
SWINYARD EA, 1972, ANTIEPILEPTIC DRUGS