ANTIDIABETIC and ANTIOXIDANT EFFECTS of Vitis vinifera L. LEAVES in STREPTOZOTOCIN-DIABETIC RATS

被引：0

作者：

Sendogdu, Nilufer ^{[1
]}

Aslan, Mustafa ^{[1
]}

Deliorman Orhan, Didem ^{[1
]}

Ergun, Fatma ^{[1
]}

Yesilada, Erdem ^{[1
]}

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Etiler Ankara, Turkey

来源：

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES | 2006年 / 3卷 / 01期

关键词：

Vitis vinifera; antidiabetic; hypoglycaemia; antioxidant; lipid peroxidation; MDA; GSH;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study the acute and subacute antidiabetic activities of the ethanolic extract of Vitis vinifera L. leaves were investigated. The acute effect was studied on the normoglycaemic, glucose hyperglycaemic and streptozotocin-induced diabetic rats; and the subacute effect was studied on same diabetic rats for 15 days. The blood glucose levels were measured by using blood glucose measuring strips based on glucose-oxidase method. After the subacute administration, the antioxidant activity of the extracts was investigated on the liver, kidney and the heart tissues of the experimental animals by measuring the tissue GSH and MDA levels. All of the antioxidant parameters were compared with the diabetic control group. According to the obtained data, the ethanolic extract of V. vinifera leaves at 250 mg/kg dose was found to possess a high antidiabetic and antioxidant activity. Mainly condensed tannins and flavonoids were suggested to contribute in the activities.

引用

页码：7 / 17

页数：11

共 50 条

[1] In-vivo assessment of antidiabetic and antioxidant activities of grapevine leaves (Vitis vinifera) in diabetic rats
Orhan, Nilufer
Aslan, Mustafa
Orhan, Didem Deliorman
Ergun, Fatma
Yesilada, Erdem
JOURNAL OF ETHNOPHARMACOLOGY, 2006, 108 (02) : 280 - 286
[2] Antioxidant role of mulberry leaves in streptozotocin-diabetic rats
Hu, ML
Wang, RJ
CLINICA CHIMICA ACTA, 2004, 348 (1-2) : 215 - 215
[3] Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats
Andallu, B
Varadacharyulu, NC
CLINICA CHIMICA ACTA, 2003, 338 (1-2) : 3 - 10
[4] Antidiabetic and antioxidant activities of Toddalia asiatica (L.) Lam. leaves in Streptozotocin induced diabetic rats
Irudayaraj, Santiagu Stephen
Sunil, Christudas
Duraipandiyan, Veeramuthu
Ignacimuthu, Savarimuthu
JOURNAL OF ETHNOPHARMACOLOGY, 2012, 143 (02) : 515 - 523
[5] Probable antioxidant effects of tryptophan in streptozotocin-diabetic rats
Karabay, A. Z.
Buyukbingol, Z.
FEBS JOURNAL, 2006, 273 : 168 - 168
[6] Antidiabetic effects of sage (Salvia officinalis L.) leaves in normal and streptozotocin-induced diabetic rats
Eidi, Akram
Eidi, Maryam
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2009, 3 (01) : 40 - 44
[7] Piperine, a Natural Bioenhancer, Nullifies the Antidiabetic and Antioxidant Activities of Curcumin in Streptozotocin-Diabetic Rats
Arcaro, Carlos Alberto
Gutierres, Vania Ortega
Assis, Renata Pires
Moreira, Thais Fernanda
Costa, Paulo Inacio
Baviera, Amanda Martins
Brunetti, Iguatemy Lourenco
PLOS ONE, 2014, 9 (12):
[8] Antioxidant role of mulberry leaves in streptozotocin-diabetic rats - Reply to letter to the editor
Andallu, B
CLINICA CHIMICA ACTA, 2004, 348 (1-2) : 217 - 218
[9] The effects of cold stress on the phenolic compounds and antioxidant capacity of grapevine (Vitis vinifera L.) leaves
Krol, A.
Amarowicz, R.
Weidner, S.
JOURNAL OF PLANT PHYSIOLOGY, 2015, 189 : 97 - 104
[10] Biological activities of Vitis vinifera L. leaves
Orhan, Didem Deliorman
Orhan, Niluefer
Ozcelik, Berrin
Ergun, Fatma
TURKISH JOURNAL OF BIOLOGY, 2009, 33 (04) : 341 - 348

← 1 2 3 4 5 →