MOLECULAR-CLONING AND CHARACTERIZATION OF RAT-BRAIN 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE ISOFORM-2

被引：39
|
作者：
GRAVEL, M [1 ]
DEANGELIS, D [1 ]
BRAUN, PE [1 ]
机构：
[1] MCGILL UNIV,DEPT BIOCHEM,MONTREAL H3G 1Y6,PQ,CANADA
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 1994年 / 38卷 / 03期
关键词：
2'; 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE; MYELIN; LEUCINE ZIPPER; PHOSPHORYLATION; ISOPRENYLATION;
D O I：
10.1002/jnr.490380302
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have isolated a cDNA coding for the larger isoform of the rat brain 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP2), a protein associated with myelination In the central nervous system (CNS). The complete 420 amino acid sequence was deduced from the nucleotide sequence of the cDNA. Sequence Comparisons show that rat CNP shares 96% homology with mouse, 84% with bovine, and 86% with human CNP. Errors in the published sequence of rat CNP1 have now been corrected. Comparisons with other proteins reveal several interesting conserved motifs, including two leucine repeat heptads, and two consensus motifs for phosphorylation in the N-terminal domain of CNP2. (C) 1993 Wiley-Liss, Inc.
引用
收藏
页码：243 / 247
页数：5
相关论文
共 43 条
  • [31] A family-based association study of the myelin-associated glycoprotein and 2,T-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia
    Voineskos, Aristotle N.
    de Luca, Vincenzo
    Bulgin, Natalie L.
    van Adrichem, Quinton
    Shaikh, Sajid
    Lang, Donna J.
    Honer, William G.
    Kennedy, James L.
    PSYCHIATRIC GENETICS, 2008, 18 (03) : 143 - 146
  • [32] CHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF GALACTOSYL-BETA-1-3-GLOBOSIDE IN BOVINE, HUMAN, AND RAT-BRAIN
    DASGUPTA, S
    HOGAN, EL
    VANHALBEEK, H
    JOURNAL OF NEUROCHEMISTRY, 1995, 65 (05) : 2344 - 2349
  • [33] METAMORPHIC CHANGES IN GLYCOLIPIDS AND MYELIN PROTEINS AND 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE IN BULLFROG AND AXOLOTL BRAINS
    TAMAI, Y
    KOJIMA, H
    SAITO, S
    UCHIDA, K
    KITAJIMA, R
    KOMATSU, H
    MORIYA, T
    JOURNAL OF NEUROCHEMISTRY, 1993, 60 (05) : 1854 - 1863
  • [34] IN-VIVO PHOSPHORYLATION OF 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE (CNP) - CNP IN BRAIN MYELIN IS PHOSPHORYLATED BY FORSKOLIN-SENSITIVE AND PHORBOL-ESTER-SENSITIVE PROTEIN-KINASES
    AGRAWAL, HC
    SPRINKLE, TJ
    AGRAWAL, D
    NEUROCHEMICAL RESEARCH, 1994, 19 (06) : 721 - 728
  • [35] PRIMARY DEMYELINATION INDUCED BY EXPOSURE TO TELLURIUM ALTERS MESSENGER-RNA LEVELS FOR NERVE GROWTH-FACTOR RECEPTOR, SCIP, 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, AND MYELIN PROTEOLIPID PROTEIN IN RAT SCIATIC-NERVE
    TOEWS, AD
    ECKERMANN, CE
    ROBERSON, MD
    LEE, SY
    MORELL, P
    MOLECULAR BRAIN RESEARCH, 1991, 11 (3-4): : 321 - 325
  • [36] The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579
    Hoffmann, R
    Baillie, GS
    MacKenzie, SJ
    Yarwood, SJ
    Houslay, MD
    EMBO JOURNAL, 1999, 18 (04) : 893 - 903
  • [37] Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain
    Shevtsov, P. N.
    Shevtsova, E. F.
    Savushkina, O. K.
    Burbaeva, G. Sh.
    Bachurin, S. O.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 165 (04) : 512 - 515
  • [38] Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain
    P. N. Shevtsov
    E. F. Shevtsova
    O. K. Savushkina
    G. Sh. Burbaeva
    S. O. Bachurin
    Bulletin of Experimental Biology and Medicine, 2018, 165 : 512 - 515
  • [39] Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity
    Puxeddu, Ermanno
    Uhart, Marina
    Li, Chun-Chun
    Ahmad, Faiyaz
    Pacheco-Rodriguez, Gustavo
    Manganiello, Vincent C.
    Moss, Joel
    Vaughan, Martha
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (15) : 6158 - 6163
  • [40] Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts
    Chen, Wei-Cheng
    Hsieh, Shih-Rong
    Chiu, Chun-Hwei
    Hsu, Ban-Dar
    Liou, Ying-Ming
    JOURNAL OF BIOMEDICAL SCIENCE, 2014, 21
12345