MOLECULAR-CLONING AND CHARACTERIZATION OF RAT-BRAIN 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE ISOFORM-2

被引：39

作者：

GRAVEL, M ^{[1
]}

DEANGELIS, D ^{[1
]}

BRAUN, PE ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT BIOCHEM,MONTREAL H3G 1Y6,PQ,CANADA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1994年 / 38卷 / 03期

关键词：

2'; 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE; MYELIN; LEUCINE ZIPPER; PHOSPHORYLATION; ISOPRENYLATION;

D O I：

10.1002/jnr.490380302

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have isolated a cDNA coding for the larger isoform of the rat brain 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP2), a protein associated with myelination In the central nervous system (CNS). The complete 420 amino acid sequence was deduced from the nucleotide sequence of the cDNA. Sequence Comparisons show that rat CNP shares 96% homology with mouse, 84% with bovine, and 86% with human CNP. Errors in the published sequence of rat CNP1 have now been corrected. Comparisons with other proteins reveal several interesting conserved motifs, including two leucine repeat heptads, and two consensus motifs for phosphorylation in the N-terminal domain of CNP2. (C) 1993 Wiley-Liss, Inc.

引用

页码：243 / 247

页数：5

共 43 条

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Krestinina, Olga
Galvita, Anastasia
Grachev, Dmitry
Baburina, Yulia
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[4] ISOPRENOID MODIFICATION PERMITS 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE TO BIND TO MEMBRANES
BRAUN, PE
DEANGELIS, D
SHTYBEL, WW
BERNIER, L
JOURNAL OF NEUROSCIENCE RESEARCH, 1991, 30 (03) : 540 - 544
[5] Crystal Structure of the Catalytic Fragment of 2′,3′-Cyclic nucleotide 3′-Phosphodiesterase from Human Brain
Sakamotoa, Yasumitsu
Tanaka, Nobutada
Ichimiya, Tomomi
Kurihara, Tadashi
Nakamura, Kazuo T.
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2005, 61 : C188 - C188
[6] Crystal structure of the catalytic fragment of human brain 2′,3′-cyclic-nucleotide 3′-phosphodiesterase
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Tanaka, N
Ichimiya, T
Kurihara, T
Nakamura, KT
JOURNAL OF MOLECULAR BIOLOGY, 2005, 346 (03) : 789 - 800
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DeAngelis, DA
Braun, PE
JOURNAL OF NEUROCHEMISTRY, 1996, 66 (06) : 2523 - 2531
[8] Interaction of myelin basic protein and 2′,3′-cyclic nucleotide phosphodiesterase with mitochondria
Baburina, Yu. L.
Gordeeva, A. E.
Moshkov, D. A.
Krestinina, O. V.
Azarashvili, A. A.
Odinokova, I. V.
Azarashvili, T. S.
BIOCHEMISTRY-MOSCOW, 2014, 79 (06) : 555 - 565
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LOTTSPEICH, F
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[10] C-TERMINAL CTII MOTIF OF 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE UNDERGOES CARBOXYLMETHYLATION
COX, ME
GAO, EN
BRAUN, PE
JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 39 (05) : 513 - 518

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