ABSENCE OF EPSTEIN-BARR-VIRUS CARRYING CELLS IN SYNOVIAL MEMBRANES AND SUBCUTANEOUS NODULES OF PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：16

作者：

BROUSSET, P

CAULIER, M

CANTAGREL, A

DROMER, C

MAZIERES, B

DELSOL, G

机构：

[1] CHU PURPAN, SERV RHUMATOL, F-31059 TOULOUSE, FRANCE

[2] CHU RANGUEIL, SERV RHUMATOL, F-31054 TOULOUSE, FRANCE

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1993年 / 52卷 / 08期

关键词：

D O I：

10.1136/ard.52.8.608

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives-To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. Methods-A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. Results-Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in the tissue samples investigated here. Conclusions-Although it has been suggested that the Epstein-Barr virus could play a part in the aetiology of rheumatoid arthritis, it was not detected in synovial membranes and subcutaneous lesions in this study.

引用

页码：608 / 609

页数：2

共 15 条

[11] SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS MAPS TO A T-CELL EPITOPE SHARED BY THE HLA-DW4 DR BETA-1 CHAIN AND THE EPSTEIN-BARR VIRUS GLYCOPROTEIN GP110 [J].