CHARACTERIZATION OF IMMUNOREACTIVE TNF-ALPHA MOLECULES IN THE GASTROPOD BIOMPHALARIA-GLABRATA

被引：36

作者：

OUWEMISSIOUKEMBOYER, O ^{[1
]}

PORCHET, E ^{[1
]}

CAPRON, A ^{[1
]}

DISSOUS, C ^{[1
]}

机构：

[1] INST PASTEUR,CTR IMMUNOL & BIOL PARASITAIRE,INSERM,U167,F-59019 LILLE,FRANCE

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1994年 / 18卷 / 03期

关键词：

BIOMPHALARIA GLABRATA; SCHISTOSOMA MANSONI; TUMOR NECROSIS FACTOR ALPHA; HEMOCYTES; HOST-PARASITE RELATIONSHIP;

D O I：

10.1016/0145-305X(94)90013-2

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

In recent years, several studies have demonstrated the existence of cytokine-like molecules in invertebrates, therefore suggesting that cytokines may have been conserved throughout evolution. In this study, we investigated the presence of immunoreactive TNF alpha (ir TNF alpha) in the gastropod mollusc Biomphalaria glabrata, the specific intermediate host for the trematode Schistosoma mansoni. Immunocytochemical study indicated the presence of ir TNF alpha in mollusc hemocytes corresponding to a 53-kDa molecule detected by western blot analysis. Using ELISA tests, we demonstrated the presence of substantial amounts of ir TNF alpha in hemolymph, that were significantly decreased during the S. mansoni infection. The possible role of ir TNF alpha in the regulation of mollusc immune functions and in the host-parasite relationship is discussed.

引用

页码：211 / 218

页数：8

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