THE TURNOVER OF RAT CORTICAL ALPHA-1-ADRENOCEPTORS IS NOT MODIFIED BY REPEATED ELECTROCONVULSIVE TREATMENT

被引：5

作者：

NOWAK, G ^{[1
]}

ZAK, J ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST PHARMACOL,PL-30060 KRAKOW,POLAND

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 56卷 / 06期

关键词：

D O I：

10.1111/j.1471-4159.1991.tb03459.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of repeated treatment with electroconvulsive shock (ECS) on the turnover of cortical alpha-1-adrenoceptors in rats was measured using the N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-induced irreversible receptor inactivation method. Repeated treatment with ECS did not affect parameters (the synthesis rate constant r, the degradation rate constant k) of alpha-1-adrenoceptor turnover. Because increase in the density of alpha-1-adrenoceptors in the ECS-treated group disappears later during measurement of turnover, several calculation possibilities were discussed. The present data confirm that repeated treatment with ECS produces a short-lasting up-regulation of cortical alpha-1-adrenoceptors, but does not affect the turnover of this receptor type.

引用

页码：2004 / 2006

页数：3

共 16 条

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