VINYL-CHLORIDE DEPENDENT MUTAGENSIS - EFFECTS OF LIVER EXTRACTS AND FREE-RADICALS

被引：21

作者：

GARRO, AJ ^{[1
]}

GUTTENPLAN, JB ^{[1
]}

MILVY, P ^{[1
]}

机构：

[1] CITY UNIV NEW YORK MT SINAI SCH MED, NEW YORK, NY 10029 USA

来源：

MUTATION RESEARCH | 1976年 / 38卷 / 02期

关键词：

D O I：

10.1016/0165-1161(76)90001-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenic effects of vinyl chloride (VC) on Salmonella typhimurium strain TA1530 are enhanced by mouse or rat liver extracts. The extracts prepared from mice pretreated either with vinyl chloride or the microsomal enzyme inducer, Aroclor 1254, did not produce any greater stimulation of VC-dependent mutagenesis than extracts from untreated animals. These same extracts, differed markedly in their capacity to stimulate the mutagenicity of dimethylnitrosamine (DMN), a compound which is converted to a mutagen by an NADPH dependent microsomal mixed function oxidase. The order of activity of the extracts with DMN was Aroclor pretreated > untreated > VC pretreated. The stimulatory effect of the liver extracts on VC mediated mutagenesis did not require NADPH and was still evident in liver extracts in which the microsomal mixed function oxidase system was heat inactivated. The mutagenic activity of VC was stimulated by riboflavin in the presence of light suggesting that free radicals may be involved in VC dependent mutagenesis.

引用

页码：81 / 88

页数：8

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