ALTERATION IN RABBIT BRAIN ENDOPLASMIC-RETICULUM CA2+ TRANSPORT BY FREE OXYGEN RADICALS IN-VITRO

被引：29

作者：

RACAY, P

BEZAKOVA, G

KAPLAN, P

LEHOTSKY, J

MEZESOVA, V

机构：

[1] Comenius University, Jessenius Medical School, Department of Biochemistry, 036 01 Martin

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The involvement of free oxygen radicals in ischemia-reperfusion injury is generally accepted. We describe here the loss of efficiency of reticular membranes to sequester Ca2+ due to free oxygen radical damage in vitro. Based on experimental results we suggest that the primary effect of free oxygen radicals is alteration of the lipid component of the membrane manifested in the increase of passive Ca2+ leak. Prolonged treatment of microsomes with free oxygen radical generating systems also led to the decrease of Ca2+-ATPase activity which is caused as we suppose by modulation of the lipid-Ca2+ pump interactions. A protective effect of butylated hydroxytoluene on the depression in the Ca2+ uptake and Ca2+-ATPase activities supports our suggestions. (C) 1994 Academic Press, Inc.

引用

页码：63 / 69

页数：7

共 27 条

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