ANTINEOPLASTIC AGENTS .291. ISOLATION AND SYNTHESIS OF COMBRETASTATINS A-4, A-5, AND A-6

被引：406

作者：

PETTIT, GR ^{[1
]}

SINGH, SB ^{[1
]}

BOYD, MR ^{[1
]}

HAMEL, E ^{[1
]}

PETTIT, RK ^{[1
]}

SCHMIDT, JM ^{[1
]}

HOGAN, F ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 10期

关键词：

D O I：

10.1021/jm00010a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South Africa, have been investigated. Subsequently we isolated a series of closely related bibenzyls, stilbenes, and phenanthrenes from C. caffrum. Some of the stilbenes proved to be potent antimitotic agents which inhibited both tubulin polymerization and the binding of colchicine to tubulin. Combretastatin A-4 has been shown to be the most potent cancer cell growth inhibitor of the series. Presently this cis-stilbene is the most effective inhibitor of colchicine binding to tubulin and the simplest natural product yet described with such potent antitubulin effects. Combretastatin A-4, A-5, and A-6 were also found to inhibit growth of Neisseria gonorrhoeae. Details of the isolation and syntheses of combretastatins A-4 (2a), A-5 (2c), and A-6 (3a) have been described.

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页码：1666 / 1672

页数：7

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