ENANTIOSELECTIVE REACTION OF AN IMINE WITH METHYLLITHIUM CATALYZED BY A CHIRAL LIGAND

被引：66

作者：

INOUE, I

SHINDO, M

KOGA, K

KANAI, M

TOMIOKA, K

机构：

[1] OSAKA UNIV,INST SCI & IND RES,IBARAKI,OSAKA 567,JAPAN

[2] TANABE SEIYAKU CO LTD,ORGAN CHEM RES LAB,TODA,SAITAMA 335,JAPAN

[3] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 10期

关键词：

D O I：

10.1016/0957-4166(95)00331-I

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantioselective reaction of benzaldehyde 4-anisidineimine 1 with methyllithium in toluene was mediated by a series of chiral aminoethers 3-11 to give the corresponding amine 2 in good to moderate ee. The chiral tridentate aminoethers 7-11 are superior to the bidentate ligands 3-6, Lithium bromide affects significantly the enantioselectivity in the catalytic reaction, but not in the stoichiometric reaction.

引用

页码：2527 / 2533

页数：7

共 21 条

[1]

Bosnich B., 1986, ASYMMETRIC CATALYSIS

[2]

BUNN BJ, 1993, J ORG CHEM, V58, P532

[3] PREPARATION AND ACTIVITY OF BETA-SUBSTITUTED ACETYLCHOLINE IODIDES [J].