CALCULATION OF HYDROPHOBIC CONSTANT (LOG P) FROM PI AND F CONSTANTS

被引:342
作者
LEO, A [1 ]
JOW, PYC [1 ]
SILIPO, C [1 ]
HANSCH, C [1 ]
机构
[1] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711
关键词
D O I
10.1021/jm00243a001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:865 / 868
页数:4
相关论文
共 20 条
[1]   ACTIVITY OF CNS DEPRESSANTS RELATED TO HYDROPHOBICITY [J].
BARKER, JL .
NATURE, 1974, 252 (5478) :52-54
[2]  
BARTINEK K, 1972, BIOKHIMIYA, V37, P1245
[3]  
COHEN GM, 1973, MOL PHARMACOL, V9, P383
[4]   ORTHO-EFFECTS IN STRUCTURE-ACTIVITY STUDIES - SHIELDING OF HYDROXYL BY ALKYL-GROUPS [J].
DEARDEN, JC ;
TUBBY, JH .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1974, 26 :P73-P74
[5]   CHEMICOBIOLOGICAL INTERACTIONS AND USE OF PARTITION-COEFFICIENTS IN THEIR CORRELATION [J].
DUNN, WJ ;
HANSCH, C .
CHEMICO-BIOLOGICAL INTERACTIONS, 1974, 9 (02) :75-95
[6]   SPECIFICITY OF ALPHA-CHYMOTRYPSIN - SEPARATION OF POLAR, STERIC, AND SPECIFIC EFFECTS IN ALPHA-CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF ACYL-SUBSTITUTED PARA-NITROPHENYL ESTERS [J].
DUPAIX, A ;
BECHET, JJ ;
ROUCOUS, C .
BIOCHEMISTRY, 1973, 12 (14) :2559-2566
[7]   PHYSICOCHEMICAL PARAMETERS FOR STRUCTURE-ACTIVITY-STUDIES OF SUBSTITUTED PHENYL N-METHYLCARBAMATES [J].
FUJITA, T ;
KAMOSHITA, K ;
NISHIOKA, T ;
NAKAJIMA, M .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1974, 38 (AUG) :1521-1528
[8]   ADDITIVE-CONSTITUTIVE CHARACTER OF PARTITION COEFFICIENTS [J].
HANSCH, C ;
NIKAITANI, D ;
LEO, A .
JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (20) :3090-+
[9]   PARTITION-COEFFICIENTS AND STRUCTURE-ACTIVITY RELATIONSHIP OF ANESTHETIC-GASES [J].
HANSCH, C ;
VITTORIA, A ;
SILIPO, C ;
JOW, PYC .
JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (06) :546-548
[10]   EFFECT OF INTRAMOLECULAR HYDROPHOBIC BONDING ON PARTITION COEFFICIENTS [J].
HANSCH, C ;
ANDERSON, SM .
JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (08) :2583-&