ACTH RESPONSE INDUCED BY INTERLEUKIN-1 IS MEDIATED BY CRF SECRETION STIMULATED BY HYPOTHALAMIC PGE

被引：104
|
作者：
WATANABE, T
MORIMOTO, A
SAKATA, Y
MURAKAMI, N
机构：
[1] Department of Physiology, Yamaguchi University School of Medicine, Ube Yamaguchi
来源：
EXPERIENTIA | 1990年 / 46卷 / 05期
关键词：
ACTH; acute phase response; corticotropin releasing factor; Hypothalamus; interleukin-1; prostaglandin;
D O I：
10.1007/BF01954238
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1α (IL-1α). The present results show that ACTH responses induced by intravenous injection of IL-1α were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2. © 1990 Birkhäuser Verlag.
引用
收藏
页码：481 / 484
页数：4
相关论文
共 50 条
  • [41] SAIREITO (A CHINESE HERBAL DRUG)-STIMULATED SECRETION AND SYNTHESIS OF PITUITARY ACTH ARE MEDIATED BY HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR
    NAKANO, Y
    SUDA, T
    TOZAWA, F
    DOBASHI, I
    SATO, Y
    OHMORI, N
    SUMITOMO, T
    DEMURA, H
    NEUROSCIENCE LETTERS, 1993, 160 (01) : 93 - 95
  • [42] Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
    Conos, S. A.
    Lawlor, K. E.
    Vaux, D. L.
    Vince, J. E.
    Lindqvist, L. M.
    CELL DEATH AND DIFFERENTIATION, 2016, 23 (11): : 1827 - 1838
  • [43] Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
    S A Conos
    K E Lawlor
    D L Vaux
    J E Vince
    L M Lindqvist
    Cell Death & Differentiation, 2016, 23 : 1827 - 1838
  • [44] INTERFERONS AS INHIBITORS OF INTERLEUKIN-1 INDUCED INTERLEUKIN-1 SYNTHESIS
    SCHINDLER, R
    GHEZZI, P
    DINARELLO, CA
    LYMPHOKINE RESEARCH, 1989, 8 (03): : 275 - 280
  • [45] Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta
    Kang, M
    Yoshimatsu, H
    Chiba, S
    Kurokawa, M
    Ogawa, R
    Tamari, Y
    Tatsukawa, M
    Sakata, T
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1995, 269 (06) : R1308 - R1313
  • [46] UV INDUCED EXACERBATION IN LUPUS IS MEDIATED BY CUTANEOUS INTERLEUKIN-1
    SAUDER, DN
    WONG, D
    LASKIN, CA
    CLINICAL RESEARCH, 1988, 36 (03): : A379 - A379
  • [47] Role of hypothalamic interleukin-1β in fever induced by cecal ligation and puncture in rats
    Gourine, AV
    Rudolph, K
    Tesfaigzi, J
    Kluger, MJ
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (03) : R754 - R761
  • [48] INHIBITION OF LIPOPOLYSACCHARIDE-INDUCED MONOCYTE INTERLEUKIN-1 SECRETION BY GANGLIOSIDES
    CAVAILLON, JM
    FITTING, C
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1986, 16 (08) : 1009 - 1012
  • [49] Iron potentiates microglial interleukin-1β secretion induced by amyloid-β
    Nnah, Israel C.
    Lee, Chih-Hao
    Wessling-Resnick, Marianne
    JOURNAL OF NEUROCHEMISTRY, 2020, 154 (02) : 177 - 189
  • [50] Pattern of interleukin-1β secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Gattorno, Marco
    Tassi, Sara
    Carta, Sonia
    Delfino, Laura
    Ferlito, Francesca
    Pelagatti, Maria Antonietta
    D'Osualdo, Andrea
    Buoncompagni, Antonella
    Alpigiani, Maria Giannina
    Alessio, Maria
    Martini, Alberto
    Rubartelli, Anna
    ARTHRITIS AND RHEUMATISM, 2007, 56 (09): : 3138 - 3148
12345