ACTH RESPONSE INDUCED BY INTERLEUKIN-1 IS MEDIATED BY CRF SECRETION STIMULATED BY HYPOTHALAMIC PGE

被引：104
|
作者：
WATANABE, T
MORIMOTO, A
SAKATA, Y
MURAKAMI, N
机构：
[1] Department of Physiology, Yamaguchi University School of Medicine, Ube Yamaguchi
来源：
EXPERIENTIA | 1990年 / 46卷 / 05期
关键词：
ACTH; acute phase response; corticotropin releasing factor; Hypothalamus; interleukin-1; prostaglandin;
D O I：
10.1007/BF01954238
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1α (IL-1α). The present results show that ACTH responses induced by intravenous injection of IL-1α were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2. © 1990 Birkhäuser Verlag.
引用
收藏
页码：481 / 484
页数：4
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