ACTH RESPONSE INDUCED BY INTERLEUKIN-1 IS MEDIATED BY CRF SECRETION STIMULATED BY HYPOTHALAMIC PGE

被引：104

作者：

WATANABE, T

MORIMOTO, A

SAKATA, Y

MURAKAMI, N

机构：

[1] Department of Physiology, Yamaguchi University School of Medicine, Ube Yamaguchi

来源：

EXPERIENTIA | 1990年 / 46卷 / 05期

关键词：

ACTH; acute phase response; corticotropin releasing factor; Hypothalamus; interleukin-1; prostaglandin;

D O I：

10.1007/BF01954238

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1α (IL-1α). The present results show that ACTH responses induced by intravenous injection of IL-1α were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2. © 1990 Birkhäuser Verlag.

引用

页码：481 / 484

页数：4

共 18 条

[1]

[Anonymous], 1979, STEREOTAXIC ATLAS RA

[2] CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1 [J].