Update on amniotic membrane transplantation

被引：144

作者：

Liu, Jingbo ^{[1
,2
]}

Sheha, Hosam ^{[1
,3
]}

Fu, Yao ^{[1
,4
]}

Liang, Lingyi ^{[5
]}

Tseng, Scheffer C. G. ^{[1
]}

机构：

[1] Ocular Surface Ctr, 7000 SW,97 Ave,Suite 213, Miami, FL 33173 USA

[2] Eye Hosp, Wenzhou Med Coll, Wenzhou 325000, Peoples R China

[3] Res Inst Ophthalmol, Cairo, Egypt

[4] Shanghai Jiao Tong Univ, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai 200011, Peoples R China

[5] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Peoples R China

来源：

EXPERT REVIEW OF OPHTHALMOLOGY | 2010年 / 5卷 / 05期

基金：

中国国家自然科学基金;

关键词：

amniotic membrane; cryopreservation; fibrosis; inflammation; ocular surface; reconstruction; regenerative medicine; tissue engineering; wound healing;

D O I：

10.1586/EOP.10.63

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Cryopreserved amniotic membrane modulates adult wound healing by promoting epithelialization while suppressing stromal inflammation, angiogenesis and scarring. Such clinical efficacies of amniotic membrane transplantation have been reported in several hundred publications for a wide spectrum of ophthalmic indications. The success of the aforementioned therapeutic actions prompts investigators to use amniotic membrane as a surrogate niche to achieve ex vivo expansion of ocular surface epithelial progenitor cells. Further investigation into the molecular mechanism whereby amniotic membrane exerts its actions will undoubtedly reveal additional applications in the burgeoning field of regenerative medicine. This article will focus on recent advances in amniotic membrane transplantation and expand to cover its clinical uses beyond the ocular surface.

引用

页码：645 / 661

页数：17

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