PROTECTIVE EFFECT OF MONOCLONAL-ANTIBODIES TO NEWCASTLE-DISEASE VIRUS IN PASSIVE-IMMUNIZATION

被引：37

作者：

UMINO, Y ^{[1
]}

KOHAMA, T ^{[1
]}

SATO, TA ^{[1
]}

SUGIURA, A ^{[1
]}

机构：

[1] NATL INST HLTH, DEPT MEASLES VIRUS, GAKUEN 4-7-1, MUSASHI MURAYAMA, TOKYO 19012, JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-5-1199

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of monoclonal antibodies (MAbs) against the haemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins and the matrix (M) protein of Newcastle disease virus (NDV) were tested for protective effects in passive immunization of newborn chickens against challenge with a virulent heterologous strain of NDV (Italien). MAbs with high virus-neutralizing activity directed to one antigenic site of the HN protein delayed virus growth and significantly prolonged survival time, but all chickens eventually succumbed to infection. MAbs directed to two antigenic sites of the F protein completely suppressed virus growth and prevented death of chickens, although the neutralizing activities of these anti-F MAbs were lower than those of the above anti-HN MAbs. Combined administration of the anti-HN and anti-F MAbs had a synergistic protective effect, but no protective effects were shown by MAbs against the M protein.

引用

页码：1199 / 1203

页数：5

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