PROCARBAZINE SPERMATOGENESIS TOXICITY - DEUTERIUM-ISOTOPE EFFECTS POINT TO REGIOSELECTIVE METABOLISM IN MICE

被引：13

作者：

YOST, GS ^{[1
]}

HORSTMAN, MG ^{[1
]}

ELWALILY, AF ^{[1
]}

GORDON, WP ^{[1
]}

NELSON, SD ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH PHARM,DEPT MED CHEM,SEATTLE,WA 98195

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1985年 / 80卷 / 02期

关键词：

D O I：

10.1016/0041-008X(85)90089-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：316 / 322

页数：7

共 28 条

[1] OXIDATION OF P-(N1-METHYLHYDRAZINO METHYL)-N-ISOPROPYL BENZAMIDE (PROCARBAZINE) TO METHYLAZO DERIVATIVE AND OXIDATIVE CLEAVAGE OF N2-C BOND IN ISOLATED PERFUSED RAT LIVER [J].

BAGGIOLINI, M ;

DEWALD, B ;

AEBI, H .

BIOCHEMICAL PHARMACOLOGY, 1969, 18 (09) :2187-+

[2]

BAILLIE TA, 1981, PHARMACOL REV, V33, P81

[3]

Chapman R. M., 1984, TOXICITY CHEMOTHERAP, P343

[4] FETAL MALFORMATIONS PRODUCED IN RATS BY N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-P-TOLUAMIDE HYDROCHLORIDE (PROCARBAZINE) [J].

CHAUBE, S ;

MURPHY, ML .

TERATOLOGY, 1969, 2 (01) :23-+

[5]

CHRYSSANTHOU CP, 1983, FERTIL STERIL, V39, P97

[6]

COOMES MW, 1983, DRUG METAB DISPOS, V11, P550

[7] METHANE FORMATION IN VIVO FROM N-ISOPROPYL A(2-METHYLHYDRAZINO)-P-IOLUAMIDE HYDROCHLORIDE A TUMOR-INHIBITING METHYLHYDRAZINE DERIVATIVE [J].

DOST, FN ;

REED, DJ .

BIOCHEMICAL PHARMACOLOGY, 1967, 16 (09) :1741-&

[8]

DUNN DL, 1979, CANCER RES, V39, P4555

[9]

GATEHOUSE DG, 1983, CARCINOGENESIS, V4, P347

[10]

KELLY MG, 1968, J NATL CANCER I, V40, P1027

← 1 2 3 →