EMODIN, A PROTEIN TYROSINE KINASE INHIBITOR FROM POLYGONUM-CUSPIDATUM

被引：158

作者：

JAYASURIYA, H ^{[1
]}

KOONCHANOK, NM ^{[1
]}

GEAHLEN, RL ^{[1
]}

MCLAUGHLIN, JL ^{[1
]}

CHANG, CJ ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 05期

关键词：

D O I：

10.1021/np50083a026

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-directed fractionation of a Chinese medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of an anthraquinone, emodin [1], as a strong inhibitor of a protein tyrosine kinase (p56lck) partially purified from bovine thymus. Comparison of the IC50 values of emodin for protein tyrosine kinase inhibitory activity with physcion [2] and emodin-O8-D-glucoside [3], also isolated from the same plant, reveal the importance of the hydroxyl groups at C-6 and C-8 for the observed activity.

引用

页码：696 / 698

页数：3

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