STRUCTURE OF SYRINGOTOXIN, A BIOACTIVE METABOLITE OF PSEUDOMONAS-SYRINGAE PV SYRINGAE

被引：74
|
作者：
BALLIO, A
BOSSA, F
COLLINA, A
GALLO, M
IACOBELLIS, NS
PACI, M
PUCCI, P
SCALONI, A
SEGRE, A
SIMMACO, M
机构：
[1] UNIV ROME LA SAPIENZA, DEPARTIMENTO SCI BIOL, PIAZZALE ALDO MORO 5, I-00185 ROME, ITALY
[2] UNIV ROME LA SAPIENZA, CNR, CTR BIOL MOLEC, I-00185 ROME, ITALY
[3] CNR, IST STRUTTURIST CHIM G GIACOMELLO, I-00016 MONTELIBRETTI STN, ITALY
[4] UNIV FEDERICO 2, CNR, SERV SPETTROMETRIA MASSA, I-80134 NAPLES, ITALY
[5] CNR, IST TOSSINE & MICOTOSSINE PARASSITI VEGETALI, I-70126 BARI, ITALY
[6] UNIV TOR VERGATA, DIPARTIMENTO SCI & TECNOL CHIM, I-00173 ROME, ITALY
来源：
FEBS LETTERS | 1990年 / 269卷 / 02期
关键词：
Lipodepsipeptide; Phytotoxin; Pseudomonas syringae pv. syringae; Syringotoxin;
D O I：
10.1016/0014-5793(90)81197-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The covalent structure of syringotoxin, a bioactive metabolite of Pseudomonas syringae pv. syringae isolates, pathogenic on various species of citrus trees, has been deduced from ID and 2D 1H- and 13C-NMR spectra combined with extensive FAB-MS data and results of some chemical reactions. Similarly to syringomicins and syringostatins, produced by other plant pathogenic strains of P. syringae pv. syringae, syringotoxin is a lipodep-sinonapeptide. Its peptide moiety corresponds to Ser-Dab-Gly-Hse-Om-aThr-Dhb-(3-OH)Asp-(4-Cl)Thr with the terminal carboxy group closing a macrocyclic ring on the OH group of the N-terminal Ser, which in turn is N-acetylated by 3-hydroxytetradecanoic acid. © 1990.
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页码：377 / 380
页数：4
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