Prescribing Warfarin to a Patient with Oesophageal Varices-A Case Report and Review of the Literature

被引：0

作者：

George, Jayan ^{[1
]}

Haboubi, Hasan ^{[2
]}

机构：

[1] Sheffield Teaching Hosp NHS Fdn Trust, Gen Surg Dept, Herries Rd, Sheffield S5 7AU, S Yorkshire, England

[2] Swansea Univ, Canc Biomarkers Grp, Singleton Pk, Swansea SA2 8PP, W Glam, Wales

来源：

REPORTS | 2018年 / 1卷 / 03期

关键词：

Factor V Leiden; Gastrointestinal Hemorrhage; portal vein; portosystemic shunt; anticoagulation;

D O I：

10.3390/reports1030018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the case of a 42-year old man who presented with melaena. He was found to have bleeding varices during endoscopic investigation. Subsequent investigation revealed the aetiology to be a portal vein thrombosis (PVT) due to an underlying pro-coagulable state (Factor V Leiden). He was managed with cautious anticoagulation but suffered a life-threatening upper gastrointestinal bleed that was not amenable to endoscopic treatment or transjugular intrahepatic portosystemic shunting (TIPS). As such, the only therapeutic option involved the pursuit of surgical shunt operations. We review the literature regarding this atypical cause of GI-bleeding and discuss medical and surgical considerations for the management of such patients.

引用

页数：5

共 13 条

[1] Prognostic factors in noncirrhotic patients with splanchnic vein thromboses [J].

Amitrano, Lucio ;

Guardascione, Maria Anna ;

Scaglione, Mariano ;

Pezzullo, Luca ;

Sangiuliano, Nicola ;

Armellino, Mariano F. ;

Manguso, Francesco ;

Margaglione, Maurizio ;

Ames, Paul R. J. ;

Iannaccone, Luigi ;

Grandone, Elvira ;

Romano, Luigia ;

Balzano, Antonio .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (11) :2464-2470

[2]

Balfour George W, 1869, Edinb Med J, V14, P589

[3] Review article: the modern management of portal vein thrombosis [J].

Chawla, Y. ;

Duseja, A. ;

Dhiman, R. K. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2009, 30 (09) :881-894

[4] Portal Vein Thrombosis [J].

Chawla, Yogesh K. ;

Bodh, Vijay .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2015, 5 (01) :22-40

[5] Evolving consensus in portal hypertension - Report of the Baveno IV Consensus Workshop on methodology of diagnosis and therapy in portal hypertension [J].

de Franchis, R .

JOURNAL OF HEPATOLOGY, 2005, 43 (01) :167-176

[6] PREVALENCE OF SPONTANEOUS HEPATOFUGAL PORTAL FLOW IN LIVER-CIRRHOSIS - CLINICAL AND ENDOSCOPIC CORRELATION IN 228 PATIENTS [J].

GAIANI, S ;

BOLONDI, L ;

BASSI, SL ;

ZIRONI, G ;

SIRINGO, S ;

BARBARA, L .

GASTROENTEROLOGY, 1991, 100 (01) :160-167

[7]

LAINE L, 1991, WESTERN J MED, V155, P274

[8] Successful Treatment of Bleeding Gastric Varices with Splenectomy in a Patient with Splenic, Portal, and Mesenteric Thromboses [J].

Menasherian-Yaccobe, Lior ;

Jaqua, Nathan T. ;

Kenny, Patrick .

CASE REPORTS IN SURGERY, 2013, 2013

[9] INCIDENCE OF PORTAL-VEIN THROMBOSIS IN LIVER-CIRRHOSIS - AN ANGIOGRAPHIC STUDY IN 708 PATIENTS [J].

OKUDA, K ;

OHNISHI, K ;

KIMURA, K ;

MATSUTANI, S ;

SUMIDA, M ;

GOTO, N ;

MUSHA, H ;

TAKASHI, M ;

SUZUKI, N ;

SHINAGAWA, T ;

SUZUKI, N ;

OHTSUKI, T ;

ARAKAWA, M ;

NAKASHIMA, T .

GASTROENTEROLOGY, 1985, 89 (02) :279-286

[10] Consensus on extra-hepatic portal vein obstruction [J].

Sarin, SK ;

Sollano, JD ;

Chawla, YK ;

Amarapurkar, D ;

Hamid, S ;

Hashizume, M ;

Jafri, W ;

Kumar, A ;

Kudo, M ;

Lesmana, LA ;

Sharma, BC ;

Shiha, G ;

de Silva, HJ .

LIVER INTERNATIONAL, 2006, 26 (05) :512-519

← 1 2 →