METABOTROPIC GLUTAMATE RECEPTORS ARE INVOLVED IN TEA-INDUCED LONG-TERM POTENTIATION IN AREA CA1 OF THE HIPPOCAMPUS

被引：9

作者：

PLATT, B ^{[1
]}

BEHNISCH, T ^{[1
]}

REYMANN, KG ^{[1
]}

机构：

[1] FED INST NEUROBIOL,DEPT NEUROPHYSIOL,D-39008 MAGDEBURG,GERMANY

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 10期

关键词：

METABOTROPIC GLUTAMATE RECEPTORS (MGLURS); TEA; LONG-TERM POTENTIATION; HIPPOCAMPUS;

D O I：

10.1016/0028-3908(95)00123-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A brief application of the K+ channel blocker tetraethylammonium induces a long-lasting potentiation in the CA1 region of hippocampal slices (TEA LTP). We report here that metabotropic glutamate receptors (mGluRs) contribute to this kind of synaptic enhancement, since the mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine ((+) MCPG) inhibits TEA LTP with a concentration-dependent component.

引用

页码：1339 / 1341

页数：3

共 11 条

[1] NOVEL FORM OF LONG-TERM POTENTIATION PRODUCED BY A K+ CHANNEL BLOCKER IN THE HIPPOCAMPUS [J].

ANIKSZTEJN, L ;

BENARI, Y .

NATURE, 1991, 349 (6304) :67-69

[2] INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS [J].

BASHIR, ZI ;

BORTOLOTTO, ZA ;

DAVIES, CH ;

BERRETTA, N ;

IRVING, AJ ;

SEAL, AJ ;

HENLEY, JM ;

JANE, DE ;

WATKINS, JC ;

COLLINGRIDGE, GL .

NATURE, 1993, 363 (6427) :347-350

[3] A MOLECULAR SWITCH ACTIVATED BY METABOTROPIC GLUTAMATE RECEPTORS REGULATES INDUCTION OF LONG-TERM POTENTIATION [J].

BORTOLOTTO, ZA ;

BASHIR, ZI ;

DAVIES, CH ;

COLLINGRIDGE, GL .

NATURE, 1994, 368 (6473) :740-743

[4] INDIRECT POTENTIATION OF SYNAPTIC TRANSMISSION BY METABOTROPIC GLUTAMATE RECEPTORS IN THE RAT HIPPOCAMPAL SLICE [J].

COLLINS, DR ;

SCOLLON, JM ;

RUSSELL, DC ;

DAVIES, SN .

BRAIN RESEARCH, 1995, 684 (02) :165-171

[5] COMPETITIVE ANTAGONISM AT METABOTROPIC GLUTAMATE RECEPTORS BY (S)-4-CARBOXYPHENYLGLYCINE AND (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE [J].

EATON, SA ;

JANE, DE ;

JONES, PLS ;

PORTER, RHP ;

POOK, PCK ;

SUNTER, DC ;

UDVARHELYI, PM ;

ROBERTS, PJ ;

SALT, TE ;

WATKINS, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1993, 244 (02) :195-197

[6] 2 COMPONENTS OF LONG-TERM POTENTIATION INDUCED BY DIFFERENT PATTERNS OF AFFERENT ACTIVATION [J].

GROVER, LM ;

TEYLER, TJ .

NATURE, 1990, 347 (6292) :477-479

[7]

HANSE E, 1994, J NEUROSCI, V14, P5028

[8] DISTINCT LTP INDUCTION MECHANISMS - CONTRIBUTION OF NMDA RECEPTORS AND VOLTAGE-DEPENDENT CALCIUM CHANNELS [J].

HUBER, KM ;

MAUK, MD ;

KELLY, PT .

JOURNAL OF NEUROPHYSIOLOGY, 1995, 73 (01) :270-279

[9] METABOTROPIC GLUTAMATE RECEPTORS - SYNAPTIC TRANSMISSION, MODULATION, AND PLASTICITY [J].

NAKANISHI, S .

NEURON, 1994, 13 (05) :1031-1037

[10]

PETROZZINO JJ, 1995, HIPPOCAMPUS, V4, P546

← 1 2 →