LIVER AND BONE MARROW STEM/PROGENITOR CELLS AS REGULATORS OF REPARATIVE REGENERATION OF DAMAGED LIVER

被引:0
作者
Lundup, A. V. [1 ]
Onishchenko, N. A. [1 ]
Shagidulin, M. Y. [1 ]
Krasheninnikov, M. E. [1 ]
机构
[1] Academician VI Shumakov Fed Res Ctr Transplantol, Moscow, Russia
来源
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2010年 / 12卷 / 02期
关键词
oval cells; bone marrow cells; liver insufficiency;
D O I
暂无
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
In this review the modern information about effectiveness of liver insufficiency treatment by stem/progenitor cells of liver (oval cells) and bone marrow (hemopoietic cells and mesenchymal cells) was presented. It is shown that medical action of these cells is referred on normalization of liver cell interaction and reorganization of processes of a reparative regeneration in damaged liver. It is believed that application of mesenchymal stromal cells from an autological bone marrow is the most perspective strategy. However, for definitive judgement about regenerative possibilities of the autological bone marrow cells it is necessary to carry out large-scale double blind clinical researches.
引用
收藏
页码:100 / 107
页数:8
相关论文
共 44 条
[1]   Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation [J].
Asai, Keiko ;
Tamakawa, Susumu ;
Yamamoto, Masahiro ;
Yoshie, Masumi ;
Tokusashi, Yoshihiko ;
Yaginuma, Yuji ;
Kasai, Shinichi ;
Ogawa, Katsuhiro .
LIVER INTERNATIONAL, 2006, 26 (05) :595-603
[2]   Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis [J].
Aziz, M. T. Abdel ;
Atta, H. M. ;
Mahfouz, S. ;
Fouad, H. H. ;
Roshdy, N. K. ;
Ahmed, H. H. ;
Rashed, L. A. ;
Sabry, D. ;
Hassouna, A. A. ;
Hasan, N. M. .
CLINICAL BIOCHEMISTRY, 2007, 40 (12) :893-899
[3]   Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury [J].
Carvalho, Adriana B. ;
Quintanilha, Lutz Fernando ;
Dias, Juliana V. ;
Paredes, Bruno D. ;
Mannheimer, Elida G. ;
Carvalho, Felipe G. ;
Asensi, Karina D. ;
Gutfilen, Bianca ;
Fonseca, Lea Mirian B. ;
Resende, Celia Maria C. ;
Rezende, Guilherme F. M. ;
Takiya, Christina M. ;
De Carvalho, Antonio Carlos Campos ;
Goldenberg, Regina C. S. .
STEM CELLS, 2008, 26 (05) :1307-1314
[4]   Efficient generation of human hepatocytes by the intrahepatic delivery of clonal human mesenchymal stem cells in fetal sheep [J].
Chamberlain, Jason ;
Yamagami, Takashi ;
Colletti, Evan ;
Theise, Neil D. ;
Desai, Jyoti ;
Frias, Ana ;
Pixley, John ;
Zanjani, Esmail D. ;
Porada, Christopher D. ;
Almeida-Porada, Graca .
HEPATOLOGY, 2007, 46 (06) :1935-1945
[5]   The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis [J].
Dai, Long-Jun ;
Li, Hong Ying ;
Guan, Li-Xue ;
Ritchie, Gordon ;
Zhou, Jeff X. .
STEM CELL RESEARCH, 2009, 2 (01) :16-25
[6]   Hematopoietic stem cell trafficking in liver injury [J].
Dalakas, E ;
Newsome, PN ;
Harrison, DJ ;
Plevris, JN .
FASEB JOURNAL, 2005, 19 (10) :1225-1231
[7]   Liver stem cells: A scientific and clinical perspective [J].
Dan, Yock Young ;
Yeoh, George C. .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2008, 23 (05) :687-698
[8]   Portal application of autologous CD133+ bone marrow cells to the liver:: A novel concept to support hepatic regeneration [J].
Esch, JSA ;
Knoefel, WT ;
Klein, M ;
Ghodsizad, A ;
Fuerst, G ;
Poll, LW ;
Piechaczek, C ;
Burchardt, ER ;
Feifel, N ;
Stoldt, V ;
Stockschläder, M ;
Stoecklein, N ;
Tustas, RY ;
Eisenberger, CF ;
Peiper, M ;
Häussinger, D ;
Hosch, SB .
STEM CELLS, 2005, 23 (04) :463-470
[9]   MARS and prometheus: Our clinical experience in acute chronic liver failure [J].
Faenza, S. ;
Baraldi, O. ;
Bernardi, M. ;
Bolondi, L. ;
Coli, L. ;
Cucchetti, A. ;
Donati, G. ;
Gozzetti, F. ;
Lauro, A. ;
Mancini, E. ;
Pinna, A. D. ;
Piscaglia, F. ;
Rasciti, L. ;
Ravaioli, M. ;
Ruggeri, G. ;
Santoro, A. ;
Stefoni, S. .
TRANSPLANTATION PROCEEDINGS, 2008, 40 (04) :1169-1171
[10]   Mechanisms of liver regeneration and their clinical implications [J].
Fausto, N ;
Riehle, KJ .
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, 2005, 12 (03) :181-189