THE EFFECT OF PLATELET-ACTIVATING FACTOR ON [C-14] AMINOPYRINE UPTAKE BY ISOLATED GUINEA-PIG PARIETAL-CELLS

被引：7
|
作者：
NOGAMI, M
SUKO, M
MIYAMOTO, T
机构：
[1] Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 03期
关键词：
D O I：
10.1016/0006-291X(90)91135-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
C16- and C18- platelet-activating factor (PAF) at 10-6M enhanced the uptake of [14C]aminopyrine (AP) by isolated guinea pig parietal cells. This increase was inhibited by a PAF antagonist CV-6209. In a medium with a low calcium (Ca2+) concentration (2 μM), this increase was not observed, which indicates that the increase of AP uptake by PAF is dependent on extracellular Ca2+. PAF and lyso-PAF showed no effect on AP uptake in the presence of histamine or carbachol. © 1990.
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页码：1047 / 1052
页数：6
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