OUTCOME OF PATIENTS WITH BRAIN METASTASES AFTER COMBINED-MODALITY THERAPY IN SMALL-CELL LUNG-CANCER (SCLC) - A RETROSPECTIVE STUDY

被引：3

作者：

VESLEMES, M ^{[1
]}

POLYZOS, A ^{[1
]}

LATSI, P ^{[1
]}

DIMITROULIS, J ^{[1
]}

DIMAKOU, K ^{[1
]}

JORDANOGLOU, J ^{[1
]}

机构：

[1] UNIV ATHENS,SOTIRIA HOSP,DEPT PULMONOL,GR-11527 ATHENS,GREECE

来源：

JOURNAL OF CHEMOTHERAPY | 1995年 / 7卷 / 05期

关键词：

SMALL CELL LUNG CANCER; BRAIN RADIOTHERAPY; COMBINED MODALITY THERAPY; BRAIN METASTASIS;

D O I：

10.1179/joc.1995.7.5.460

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors evaluated the role of whole brain radiotherapy (WBRT) on the outcome of brain metastasis and survival in 41 patients with small cell lung cancer (SCLC) treated in their department. In addition to chemotherapy, radiotherapy was given to the primary site in all responder patients. Six patients presented brain metastasis initially and 10 patients after the fourth course of chemotherapy. Brain metastases were symptomatic in 12 of 16 patients with a median time of 5 months (1-14) until symptoms developed. All patients but 2 with brain metastasis received WBRT (30 Gy in 10 fractions) in addition to chemotherapy. The median survival time of patients with brain metastasis was 8.3 months (3.5 to 16) compared to 12 months (4 to 34+) for patients without brain metastasis. In addition, the median survival time for patients with brain metastasis who responded to systemic chemotherapy was better than that of nonresponders, The authors found no improvement in survival in patients who received concomitant WBRT after chemotherapy compared to patients who received WBRT after completion of chemotherapy. In conclusion, the role of consolidating cranial irradiation in addition to chemotherapy in SCLC patients is unclear and warrants prospective randomized studies.

引用

页码：460 / 462

页数：3

共 6 条

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