ENANTIOSELECTIVE 1,2-ADDITION OF GRIGNARD-REAGENTS TO ALDEHYDES USING CHIRAL DIAMINES

被引：36

作者：

NAKAJIMA, M ^{[1
]}

TOMIOKA, K ^{[1
]}

KOGA, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON | 1993年 / 49卷 / 43期

关键词：

D O I：

10.1016/S0040-4020(01)80177-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective 1,2-addition of Grignard reagents to aldehydes using chiral diamine 1, 2 was examined. High ee (up to 75%) of carbinol was achieved by the reaction of arylmagnesium bromide and benzaldehyde with chiral diamine. Utilizing 2,4,6-trimethylphenoxyaluminum dichloride 6 as a coordinating agent to benzaldehyde, enantioselectivity of the addition of alkylmagnesium bromide was dramatically increased (up to 70%).

引用

页码：9751 / 9758

页数：8

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