1-(1-NAPHTHYL)ETHYLAMINE AND DERIVATIVES THEREOF AS CHIRAL MODIFIERS IN THE ENANTIOSELECTIVE HYDROGENATION OF ETHYL PYRUVATE OVER PT-ALUMINA

被引：57

作者：

HEINZ, T

WANG, GZ

PFALTZ, A

MINDER, B

SCHURCH, M

MALLAT, T

BAIKER, A

机构：

[1] UNIV BASEL,INST ORGAN CHEM,CH-4056 BASEL,SWITZERLAND

[2] ETH ZURICH,DEPT CHEM ENGN & IND CHEM,CH-8092 ZURICH,SWITZERLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 14期

关键词：

D O I：

10.1039/c39950001421

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic quantities of (R)- or (S)-1-(1-naphthyl)ethylamine induce up to 82% e.e. in the hydrogenation of ethyl pyruvate over Pt-alumina, the actual modifier responsible for enantioselection being the secondary amine resulting from imine formation with ethyl pyruvate and subsequent reduction of the C=N bond; a series of related derivatives has been prepared by reductive amination and tested as chiral modifiers.

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页码：1421 / 1422

页数：2

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