DISSOLUTION OF FUROSEMIDE FROM SUSTAINED-RELEASE MICROCAPSULES PREPARED BY THE PHASE-SEPARATION TECHNIQUE

Sustained release microcapsules of furosemide with Eudragit RL 100 (furosemide - RL 100) were prepared using the phase separation technique. Results of the dissolution rate studies, in Sorensen phosphate buffer pH 7.4, showed a good sustained effect of the prepared microcapsules. Increasing the drug-to-polymer ratio resulted in a decrease in dissolution, while increased dissolution was obtained by increasing the pH of the dissolution medium. Dosing of healthy human volunteers with sustained release microcapsules resulted in a reduced and sustained urine volume, compared to the profuse diuresis obtained with the conventional furosemide capsules.