HUMAN-ANTIBODY RESPONSE TO PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-2 IS SEROGROUP SPECIFIC AND PREDOMINANTLY OF THE IMMUNOGLOBULIN G3 SUBCLASS

被引：157

作者：

TAYLOR, RR ^{[1
]}

SMITH, DB ^{[1
]}

ROBINSON, VJ ^{[1
]}

MCBRIDE, JS ^{[1
]}

RILEY, EM ^{[1
]}

机构：

[1] UNIV EDINBURGH, INST CELL ANIM & POPULAT BIOL, DIV BIOL SCI, ASHWORTH LABS, EDINBURGH EH9 3JT, MIDLOTHIAN, SCOTLAND

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.63.11.4382-4388.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MSP2 is a merozoite surface protein of Plasmodium falciparum and, as such, is a potential component of a malaria vaccine. In this study, we have used a panel of recombinant MSP2 antigens in enzyme-linked immunosorbent assays to investigate the recognition of MSP2 by antibodies from malaria-immune human serum. These recombinant antigens include full-length proteins of serogroups A and B and fragments representing the conserved, group-specific, or repeat regions of each serogroup. Ninety-five percent of the serum samples tested contained MSP2-specific antibodies: 81% of serum samples tested responded to serogroup A, and 86% responded to serogroup B. The antibody response is directed almost exclusively towards dimorphic and polymorphic regions of MSP2; the conserved regions are rarely recognized, and antibodies to serogroups A and B do not cross-react, Interestingly, the antibody response is predominately of the cytophilic and complement-fixing subclass immunoglobulin G3.

引用

页码：4382 / 4388

页数：7

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