AN ERYTHROCYTIC LIPID COMPONENT IN YOUNG MALES AT THE ASYMPTOMATIC STAGES OF CORONARY HEART-DISEASE

The paper presents the results of investigations of primary disturbances in the composition of phospholipids (PLs) and fatty acids (FAs) of erythrocytic lipids in young males at the preclinical stage of coronary heart disease (CHD). One hundred and twenty-nine males were examined. The examinees were divided into three groups: (1) healthy subjects without CHD risk factors; (2) patients with prior myocardial infarction and (3) subjects suspected for CHD risk factors (aggravated heredity and/or smoking). Primary signs of disturbances in the erythrocytic lipid component in Group 3 subjects. The differences in the levels of some PLs, individual FAs and FA families were found to correspond to the disturbances in Group 2 patients, but they were less profound. The changes in the composition of FA in Group 3 males suggest lipid metabolic disturbances, which is a risk factor for CHD.