DNA-PROTEIN COMPLEXES NATURAL TARGETS FOR DNA-HYDROLYZING ANTIBODIES

被引：36
|
作者：
GOLOLOBOV, GV
MIKHALAP, SV
STAROV, AV
KOLESNIKOV, AF
GABIBOV, AG
机构：
[1] RUSSIAN ACAD SCI,VA ENGELHARDT MOLEC BIOL INST,MOSCOW 117901,RUSSIA
[2] UKRAINIAN ACAD SCI,KAVETSKY INST EXPTL PATHOL ONCOL & RADIOBIOL,KIEV,UKRAINE
[3] RUSSIAN ACAD MED SCI,INST VIROL,MOSCOW 109801,RUSSIA
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 1994年 / 47卷 / 2-3期
关键词：
CATALYTIC ANTIBODIES; DNA; CROSSREACTIONS; NUCLEAR STAINING; LEUKEMIA; AIDS;
D O I：
10.1007/BF02787942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sera of patients with different types of leukemia and acquired immune deficiency syndrome (AIDS) have been examined for the presence of the anti-DNA antibodies. DNA-hydrolyzing activity of antibodies was detected in the sera of patients with chronic lymphoid leukemia (CLL), pre-B-cell acute lymphoid leukemia (pre-B-All), acute myeloleukosis (AML), and AIDS in stages III and IV of the disease. In immunofluorescence tests, the DNA-hydrolyzing antibodies reacted preferentially with proliferating cell nuclei compared with resting cells. A 35-kDa factor was identified as the target for the DNA antibodies in the cell nuclei. The DNA-hydrolyzing antibody fraction from the serum of an AIDS patient crossreacted with HIV I virus proteins gp160, gp120, and p65.
引用
收藏
页码：305 / 315
页数：11
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