RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION

被引：3685

作者：

HO, DD

NEUMANN, AU

PERELSON, AS

CHEN, W

LEONARD, JM

MARKOWITZ, M

机构：

[1] SANTA FE INST,SANTA FE,NM 87501

[2] LOS ALAMOS NATL LAB,DIV THEORET,LOS ALAMOS,NM 87545

[3] ABBOTT LABS,DIV PHARMACEUT PROD,ABBOTT PK,IL 60064

来源：

NATURE | 1995年 / 373卷 / 6510期

关键词：

D O I：

10.1038/373123a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

引用

页码：123 / 126

页数：4

共 20 条

[1]

AMEISEN JC, 1991, IMMUNOL TODAY, V12, P102

[2]

CAO Y, IN PRESS AIDS RES HU

[3]

COFFIN JM, 1992, CURR TOP MICROBIOL, V176, P143

[4] INCREASED VIRAL BURDEN AND CYTOPATHICITY CORRELATE TEMPORALLY WITH CD4+ T-LYMPHOCYTE DECLINE AND CLINICAL PROGRESSION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED INDIVIDUALS [J].