LOCALIZATION OF THE HUMAN GLUCAGON GENE (GCG) TO CHROMOSOME SEGMENT 2Q36-]37

被引：32

作者：

SCHROEDER, WT

LOPEZ, LC

HARPER, ME

SAUNDERS, GF

机构：

[1] UNIV TEXAS, MD ANDERSON HOSP & TUMOR INST, CTR CANC, DEPT BIOCHEM & MOLEC BIOL, HOUSTON, TX 77030 USA

[2] AGOURON INST, LA JOLLA, CA USA

来源：

CYTOGENETICS AND CELL GENETICS | 1984年 / 38卷 / 01期

关键词：

D O I：

10.1159/000132034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hybridization of a 3H-labeled bovine glucagon c[complementary]DNA plasmid to human metaphase chromosomes revealed significant labeling of the distal portion of the long arm of chromosome 2. A large portion (37%) of the cells analyzed exhibited labeling of the 2. A significant percentage (40%) of the labeled sites on the 2 were in segment 2q36 .fwdarw. 37. The human glucagon gene (GCG) was assigned to this segment. Localization of the glucagon gene, whose chromosomal assignment was previously not known, demonstrates the general applicability of in situ hybridization as a powerful gene mapping technique.

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页码：76 / 79

页数：4

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