A NEW SYNTHESIS OF THE POTENT AND SELECTIVE ANTI-HERPESVIRUS AGENT (S)-1-[3-HYDROXY-2-(PHOSPHONYLMETHOXY)PROPYL]CYTOSINE

被引:17
作者
BRONSON, JJ [1 ]
FERRARA, LM [1 ]
HOWELL, HG [1 ]
BRODFUEHRER, PR [1 ]
MARTIN, JC [1 ]
机构
[1] CHEM PROC DEV DEPT, SYRACUSE, NY 13221 USA
关键词
D O I
10.1080/15257779008043142
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new synthetic approach to (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (3, (S)-HPMPC) is based on coupling of the heterocyclic moiety with a glycerol-derived side chain, followed by introduction of the phosphonylmethyl ether group. © 1990, Taylor & Francis Group, LLC. All rights reserved.
引用
收藏
页码:745 / 769
页数:25
相关论文
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