QUANTITATIVE MODIFICATIONS INDUCED BY ANGIOTENSIN-II ON RAT BILE SECRETION

Angiotensin II (ANG II) effects on bile secretion were studied in the rat. ANG II (0.1 mu g/kg) was injected into the jugular vein every 30 min and bile samples of 30 min were collected for 120 min. Blood arterial and portal venous pressures were simultaneously recorded before and after the administration of ANG II. Results showed that ANG II decreased bile now and the excretion of sodium, potassium, chloride and bile acids whereas it increased pH, bile osmolality and the excretion rate of bicarbonate and calcium. ANG II also led to a rapid increase in mean arterial pressure as well as portal venous pressure which reverted to control values within 1 min. The present results suggest that ANG II may modulate bile flow and the excretion rate of the different biliary constituents. We have previously investigated atrial natriuretic factor effects on bile secretion and although the atrial factor antagonizes most of ANG II biological actions, unexpectedly, ANG II effects on bile secretion were not opposite to those of atrial natriuretic peptide. The modifications induced by ANG II on bile secretion may play an important role in pathophysiological conditions such as hypertensive states with increased ANG II circulating levels.