A MIRACLE ENOUGH - THE POWER OF MICE

被引：142

作者：

PAIGEN, K

机构：

[1] The Jackson Laboratory, Bar Harbor, MA

来源：

NATURE MEDICINE | 1995年 / 1卷 / 03期

关键词：

D O I：

10.1038/nm0395-215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

“A mouse is miracle enough to stagger sextillions of infidels” Leaves of Grass, Walt Whitman The mouse has become our experimental surrogate. It is the creature we turn to to do the experiments, so important in reaching an understanding of ourselves, that are either technically impossible or morally inconceivable in human subjects. © 1995 Nature Publishing Group.

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页码：215 / 220

页数：6

相关论文

共 8 条

[1] OBESE AND DIABETES - 2 MUTANT-GENES CAUSING DIABETES-OBESITY SYNDROMES IN MICE [J].

COLEMAN, DL .

DIABETOLOGIA, 1978, 14 (03) :141-148

[2]

Davisson Muriel T., 1993, V384, P117

[3] A GENETIC-LINKAGE MAP OF THE LABORATORY RAT, RATTUS-NORVEGICUS [J].

JACOB, HJ ;

BROWN, DM ;

BUNKER, RK ;

DALY, MJ ;

DZAU, VJ ;

GOODMAN, A ;

KOIKE, G ;

KREN, V ;

KURTZ, T ;

LERNMARK, A ;

LEVAN, G ;

MAO, YP ;

PETTERSSON, A ;

PRAVENEC, M ;

SIMON, JS ;

SZPIRER, C ;

SZPIRER, J ;

TROLLIET, MR ;

WINER, ES ;

LANDER, ES .

NATURE GENETICS, 1995, 9 (01) :63-69

[4] LINKAGE OF ATHEROGENIC LIPOPROTEIN PHENOTYPE TO THE LOW-DENSITY-LIPOPROTEIN RECEPTOR LOCUS ON THE SHORT ARM OF CHROMOSOME-19 [J].

NISHINA, PM ;

JOHNSON, JP ;

NAGGERT, JK ;

KRAUSS, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (02) :708-712

[5] ATH-1, A GENE DETERMINING ATHEROSCLEROSIS SUSCEPTIBILITY AND HIGH-DENSITY-LIPOPROTEIN LEVELS IN MICE [J].

PAIGEN, B ;

MITCHELL, D ;

REUE, K ;

MORROW, A ;

LUSIS, AJ ;

LEBOEUF, RC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (11) :3763-3767

[6]

PIAGEN B, IN PRESS AM J CLIN N

[7] GENE-THERAPY ON THE SLY [J].

SLY, WS .

NATURE GENETICS, 1993, 4 (02) :105-106

[8] POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOG [J].

ZHANG, YY ;

PROENCA, R ;

MAFFEI, M ;

BARONE, M ;

LEOPOLD, L ;

FRIEDMAN, JM .

NATURE, 1994, 372 (6505) :425-432