SIGNIFICANTLY LOWER PREVALENCE OF HELICOBACTER-PYLORI IN UREMIC PATIENTS THAN IN PATIENTS WITH NORMAL RENAL-FUNCTION

被引：55

作者：

JASPERSEN, D ^{[1
]}

FASSBINDER, W ^{[1
]}

HEINKELE, P ^{[1
]}

KRONSBEIN, H ^{[1
]}

SCHORR, W ^{[1
]}

RASCHKA, C ^{[1
]}

BRENNENSTUHL, M ^{[1
]}

机构：

[1] ACAD HOSP,DEPT GASTROENTEROL,D-36043 FULDA,GERMANY

来源：

JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 05期

关键词：

PREVALENCE; HELICOBACTER PYLORI; RENAL DYSFUNCTION;

D O I：

10.1007/BF02367783

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The objective of the study was to evaluate the prevalence of Helicobacter pylori in patients with different degrees of renal function. Two hundred and twenty consecutive patients requiring gastroscopy for upper intestinal symptoms were enrolled in the study: group I (normal renal function, n = 127), group II (chronic renal failure, creatinine clearance > 5 < 90 ml/min, n = 59), and group III (hemodialysis therapy, n = 34). On endoscopy, biopsy specimens were taken for analysis of H. pylori infection by urease test and histology. The prevalence of H. pylori in patients with renal dysfunction proved to be significantly lower than that in patients with normal renal function (22.6% vs 37%, P < 0.05). The incidence of ulcer disease in patients with normal renal function was higher than that in uremic patients (14.2% vs 10.8%, not significant). These findings indicate that uremic patients seem to be partly protected against N. pylori infection.

引用

页码：585 / 588

页数：4

共 19 条

[1] Milito G., Taccone-Gallucci M., Brancaleone C., The gastrointestinal tract in uremic patients on long-term hemodialysis, Kidney Int, 17, pp. S157-S160, (1985)
[2] Ala-Kaila K., Upper gastrointestinal findings in chronic renal failure, Scand J Gastroenterol, 22, pp. 372-376, (1986)
[3] Graham D.Y., Lew G.M., Klein P.D., Et al., Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer, Ann Intern Med, 116, pp. 705-708, (1992)
[4] Ala-Kaila K., Vaajalahti P., Karvonen A.L., Kokki M., Gastric Helicobacter and upper gastrointestinal symptoms in chronic renal failure, Ann Med, 23, pp. 403-406, (1991)
[5] Offerhaus G.J., Kreuning J., Valentijn R.M., Et al., Campylobacter pylori: Prevalence and significance in patients with chronic renal failure, Clin Nephrol, 32, pp. 239-241, (1989)
[6] Conz P., Feriani M., Milan M., Et al., Campylobacter pylori infection in uremic dialyzed patients, Nephron, 55, pp. 442-443, (1990)
[7] Davenport A., Shallcross T.M., Crabtree J.E., Et al., Prevalence of Helicobacter pylori in patients with end-stage renal failure and renal transplant recipients, Nephron, 59, pp. 597-601, (1991)
[8] Shousha S., Arnaout A.H., Abbas S.H., Parkins R.A., Antral Helicobacter pylori in patients with chronic renal failure, J Clin Pathol, 43, pp. 397-399, (1990)
[9] Tielemans C., Verhas M., Glupczynski Y., Nyst J.F., Deltenre M., Dratwa M., Urea-C14 breath test screening for Campylobacter pylori infection in uraemic patients, Workshop on gastroduodenal pathology and Campylobacter pylori. Abstract book, pp. 160-172, (1988)
[10] Labenz J., Gyenes E., Ruhl G.H., Et al., Diagnosis of Helicobacter pylori colonization of gastric mucosa. A prospective comparative study of direct tests and validity of a new urease test, Med Klin, 86, pp. 461-464, (1991)

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