FIRST SYNTHESIS OF ENANTIOMERICALLY PURE N-PROTECTED BETA-AMINO-ALPHA-KETO ESTERS FROM ALPHA-AMINO-ACIDS AND DIPEPTIDES

被引：13

作者：

DARKINS, P

MCCARTHY, N

MCKERVEY, MA

ODONNELL, K

YE, T

WALKER, B

机构：

[1] QUEENS UNIV BELFAST,SCH CHEM,BELFAST BT9 5AG,ANTRIM,NORTH IRELAND

[2] QUEENS UNIV BELFAST,SCH BIOL & BIOCHEM,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)86171-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A racemization-free route from N-protected alpha-amino acids and dipeptides to N-protected beta-amino-alpha-keto esters is described, involving the sequence: diazoketone formation. Wolff rearrangement in methanol, diazo transfer, and oxidation with dimethyldioxirane.

引用

页码：195 / 198

页数：4

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