FIRST SYNTHESIS OF ENANTIOMERICALLY PURE N-PROTECTED BETA-AMINO-ALPHA-KETO ESTERS FROM ALPHA-AMINO-ACIDS AND DIPEPTIDES

被引：13
|
作者：
DARKINS, P
MCCARTHY, N
MCKERVEY, MA
ODONNELL, K
YE, T
WALKER, B
机构：
[1] QUEENS UNIV BELFAST,SCH CHEM,BELFAST BT9 5AG,ANTRIM,NORTH IRELAND
[2] QUEENS UNIV BELFAST,SCH BIOL & BIOCHEM,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
来源：
TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 02期
关键词：
D O I：
10.1016/S0957-4166(00)86171-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A racemization-free route from N-protected alpha-amino acids and dipeptides to N-protected beta-amino-alpha-keto esters is described, involving the sequence: diazoketone formation. Wolff rearrangement in methanol, diazo transfer, and oxidation with dimethyldioxirane.
引用
收藏
页码：195 / 198
页数：4
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