Amnesia in Frontotemporal Dementia with Amyotrophic Lateral Sclerosis, Masquerading Alzheimer's Disease

被引：4

作者：

Yamanami-Irioka, A. ^{[1
,3
]}

Uchihara, T. ^{[1
]}

Endo, T. ^{[2
]}

Irioka, T. ^{[3
]}

Watanabe, M. ^{[3
]}

Kitagawa, M. ^{[2
]}

Mizusawa, H. ^{[3
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Lab Struct Neuropathol, Setagaya Ku, 2-1-6 Kami Kitazawa, Tokyo 1568506, Japan

[2] Tokyo Med & Dent Univ, Dept Pathol, Tokyo, Japan

[3] Tokyo Med & Dent Univ, Dept Neurol, Tokyo, Japan

来源：

CASE REPORTS IN NEUROLOGY | 2011年 / 3卷 / 03期

关键词：

Amyotrophic lateral sclerosis; Dementia; Alzheimer's disease; Creatine kinase;

D O I：

10.1159/000331859

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 68-year-old man with a clinical diagnosis of Alzheimer's disease (AD) later developed amyotrophic lateral sclerosis (ALS), which was confirmed at autopsy at age 72 years. Because neuronal loss and AD-type pathologies (Braak stage II for neurofibrillary tangles) were scant, TDP-43-positive intracytoplasmic inclusions in hippocampal dentate granular cells and in neurons in the subiculum and amygdala, even though small in amount, may represent the earliest lesions of ALS-related dementia and could be the cause of dementia in this patient. Although the persistent elevation of creatine kinase from the onset could be a pointer to the presence of motor involvement, more accurate characterization of dementia, which may differentiate ALS-related dementia and AD, is necessary.

引用

页码：242 / 247

页数：6

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